Background
Ciprofloxacin, a fluoroquinolone, has emerged as a versatile, commonly used drug with a high toxicity profile and poor safety profile due to its pharmacokinetic and pharmacodynamic properties. Despite its high effectiveness and favorable safety profile, ciprofloxacin can lead to severe side effects, such as tendon rupture, tendon disorders, muscle atrophy and bone density loss. This study aimed to compare the safety and efficacy of the ciprofloxacin in treating fluoroquinolone-induced tendon disorders and bone loss in men with tendon rupture and muscle wasting.
Methods
This randomized, double-blind, phase 3, multicenter study evaluated the efficacy and safety of ciprofloxacin for tendon rupture and bone loss in men with tendon disorders and bone wasting (TENDO) according to the Anatomical Therapeutic Chemical classification [ATAC] criteria []. TENDO is a chronic painful and painful-tendon disease, which is characterized by the development of a ruptured tendo-synovial (PSS) and Achilles tendon (CT) [, ]. The Achilles tendon, the main tendon in the Achilles' tendon and the primary tendon of the patellar tendon (PT) are the major areas of TENDO [, ]. In addition, TENDO has a risk of tendon rupture, especially Achilles tendon rupture in people with a history of tendinitis, and a small risk of tendon deterioration after a tendon rupture []. The main purpose of the study was to evaluate the safety of the ciprofloxacin in TENDO according to the ATAC classification.
Results
A total of 24 men with a TENDO diagnosis were enrolled. All patients were treated with ciprofloxacin at a dose of 5 mg/day orally twice a day for seven days. After discontinuation of ciprofloxacin, TENDO patients had a decrease in the TENDO levels of 7.0 mg/L and a reduction of 8.3 mg/L in the Achilles tendon. Patients with a positive TENDO history had a decrease in the TENDO level of 12.2 mg/L and a reduction in the TENDO level of 8.3 mg/L in the PT. The results showed that ciprofloxacin could significantly reduce TENDO levels in patients with a positive TENDO history.
The patients who had undergone the Achilles tendon rupture and the Achilles tendon disorder had a significantly higher TENDO levels than those who had no history of TENDO in the Achilles tendon. Patients with a positive TENDO history had a significantly lower TENDO levels in patients with a positive TENDO history. However, there were no significant differences in the TENDO levels between patients with a positive TENDO history and those who had no history of TENDO.
Conclusions
The results of this study indicate that ciprofloxacin is a safe and effective alternative for tendon rupture in men with TENDO and Achilles tendon disorders.
Key wordsTendin, tendo-synovial, Achilles tendon, TENDO, Achilles tendon disorder, musculoskeletal
Received:June 28, 2018;Accepted:March 23, 2018;Published:April 28, 2018;DOI:https://doi.org/10.5884/gv0017442
Citation:Siegel, R. (2019, March 23). Ciprofloxacin: An Overview and Preliminary Results for Clinical Studies.
If you are allergic to ciprofloxacin or any other tetracycline antibiotics, you may have an increased risk of developing, a serious sexually transmitted infection (STI). People with HIV are more at risk of developing this infection, because of changes in their immune systems that can prevent them from getting the infections they need to get the help they need.
Ciprofloxacin ophthalmic ointment is used to treat people who have eye infections. It may also be used for purposes not listed in this medication guide.
It is a prescription drug. If you are not sure if you are using this medication, talk to your doctor or pharmacist before taking it. Tell your doctor if you are pregnant or may become pregnant. You can also purchase it over the counter at pharmacies. Make sure the doctor or pharmacist, who supplies the ointment, is aware of any questions you may have about using this drug. If you are getting treatment from a doctor, you may be more likely to get STIs from someone who does not have the disease.
See also Warning section.Ciprofloxacin ophthalmic ointment is a topical, oral solution containing the antibiotic ciprofloxacin. It is used to treat eye infections (such as bacterial conjunctivitis and bacterial keratitis).
Ciprofloxacin ophthalmic ointment may also be used to treat other eye infections. Tell your doctor if you are taking any other medications, including any that are available over the counter.
Your doctor may occasionally change your dose of ciprofloxacin ophthalmic ointment. Tell your doctor if you do not feel better or are experiencing any side effects.
Ciprofloxacin ophthalmic ointment may be given to treat infections of the eyes.
It is not known whether ciprofloxacin ophthalmic ointment passes into the breast milk or if it could affect the baby. Tell your doctor if you are breast-feeding. You can breastfeed in the presence of ciprofloxacin ophthalmic ointment.
It may be harmful to your unborn baby if you are taking this drug. You can also get treatment from a doctor or pharmacist.
Ciprofloxacin ophthalmic ointment may pass into the lungs. It may also be harmful to your baby if you are taking this drug.
Ciprofloxacin ophthalmic ointment is used to treat a wide range of eye infections.
It is not known if ciprofloxacin ophthalmic ointment passes into the breast milk. Your doctor may prescribe this drug if you are breastfeeding, have a baby, or if you are breast-feeding. Tell your doctor if you are breastfeeding. You can also get treatment from a doctor.
It is not known if ciprofloxacin ophthalmic ointment passes into the milk. If you are breast-feeding, you can also get treatment from a doctor.
It is not known if ciprofloxacin ophthalmic ointment passes into the lungs.
Ciprofloxacin (Cipro, ciprofloxacin hydrochloride) is a broad-spectrum antibiotic belonging to the fluoroquinolone family. It is used to treat a variety of bacterial infections, including those affecting the respiratory, urinary, and skin systems. It is effective against a broad spectrum of gram-positive and gram-negative bacteria. It is also used to treat some sexually transmitted infections such as syphilis. The active ingredient, Ciprofloxacin hydrochloride, works by inhibiting bacterial DNA gyrase, an enzyme that breaks DNA into smaller pieces. This results in the buildup of double-stranded DNA and the release of many proteins, including proteins needed for replication and transcription.
Ciprofloxacin is available in tablet form and can be administered orally or intravenously. It is effective against a wide range of bacterial infections. The active ingredient, ciprofloxacin, belongs to the fluoroquinolone class of antibiotics. Ciprofloxacin is a broad-spectrum antibiotic that is effective against a wide range of bacterial infections. The active ingredient, ciprofloxacin hydrochloride, works by inhibiting the DNA gyrase enzyme, an enzyme needed for bacterial DNA replication and transcription.
Ciprofloxacin is also available as an extended-release tablet. Extended-release forms of ciprofloxacin have been developed for oral administration. Ciprofloxacin extended-release tablets are available in a variety of dosage forms. It is important to note that extended-release tablets may not be suitable for everyone, and may have adverse effects or a higher risk of bleeding. It is also recommended to use a liquid suspension form of ciprofloxacin to minimize the risk of absorption of the medication. It is important to follow the dosage instructions provided by your healthcare provider, as well as to monitor for any potential side effects or adverse reactions while taking the medicine. Patients who have had a previous adverse reaction to ciprofloxacin may be more at risk for adverse effects or complications, especially those who are pregnant or breastfeeding. In some cases, ciprofloxacin may cause other serious side effects such as tendon rupture, muscle pain, or swelling of the hands and feet.
Ciprofloxacin and Cipro-containing products are available in a variety of forms, including extended-release tablets and liquid suspension. Ciprofloxacin extended-release tablets and liquid suspension can be used to treat infections caused by susceptible strains of bacteria and parasites. Ciprofloxacin extended-release tablets may be prescribed for children who are at risk for bleeding or who are breastfeeding. Ciprofloxacin extended-release tablets may also be used in combination with other antibiotics and/or prophylaxis for fungal infections in the treatment of certain types of infections caused by Candida.
Ciprofloxacin is an antibiotic belonging to the fluoroquinolone class of antibiotics. It works by inhibiting the DNA gyrase enzyme, an enzyme needed for bacterial DNA replication and transcription.
It is also used to treat certain types of sexually transmitted infections such as syphilis.
The active ingredient in Ciprofloxacin is ciprofloxacin hydrochloride, a quinolone antibiotic belonging to the fluoroquinolone class of antibiotics.
Ciprofloxacin (generic name: ciprofloxacin; brand names: fluoroquinolones) is a broad-spectrum antibiotic that is commonly used to treat a wide range of bacterial infections, including respiratory tract infections, skin and soft tissue infections, urinary tract infections, and sexually transmitted infections (like gonorrhea). It is available in many countries including the U. S., European Union, and other countries.
If you have diarrhea or other bacterial infection, take ciprofloxacin with a full glass of water. It can be taken with or without food.
It is important to finish the full course of treatment even if you start to feel better.
Ciprofloxacin may also be taken with or without food.
Common side effects of ciprofloxacin may include:
If any of these side effects persist or worsen, tell your doctor or pharmacist promptly.
Serious side effects may include:
It is not clear whether ciprofloxacin is the most serious or common cause of diarrhea or if it may be a risk to others. It is important to seek medical attention immediately if you experience any of these serious diarrhea-like symptoms.
Ciprofloxacin may also have unwanted effects, including nausea, vomiting, diarrhea, loss of appetite, and rash. If you experience any of these symptoms, stop taking ciprofloxacin and seek medical attention immediately.
Ciprofloxacin is available in the following doses:
For the treatment of bacterial infections, the recommended dosage of ciprofloxacin for adults ranges from 250 mg orally three times a day for five days, followed by a second dose every five days for seven days.
Ciprofloxacin is usually taken once or twice a day, but can be taken more often if you have kidney or liver disease. You should take the full course of antibiotics as prescribed.
Your doctor will determine the right dosage for you based on the type of infection you have, your body weight, and any other medical conditions you may have. To find out how this medication works for you, talk with your doctor, pharmacist, or other healthcare professional if you have any questions.
Ciprofloxacin HCL and Hydrocortisone
$3,600.90
Generic name:Ciprofloxacin HCL
Product name:CIPROFLOXACIN HCL and Hydrocortisone
Manufacturer:CIPRO, INC
Prescription medicine provided by our medical team. This medicine is dispensed by a registered U. S. pharmacy without prescription.
This medicine is available only with a valid prescription from your doctor. This medicine is not interchangeable with Ciprofloxacin HCL and Hydrocortisone. Ciprofloxacin HCL and Hydrocortisone should be used in the smallest possible dosage to maintain a consistent and stable hormonal balance. For more information, see Section 6.1.4, "Drugs, Products and Methods" in Section 6.1.1, "Dosage and Administration" in Section 6.1.4, "Dosage" in Section 6.1.5, "Pregnancy and Breastfeeding" in Section 6.1.6.
3,600.
Ciprofloxacin is an antibiotic that is commonly prescribed to treat a wide range of bacterial infections. It is effective in treating a variety of infections, such as those caused by bacteria, and is also used in the treatment of various parasitic infections. This medication can also be prescribed for the treatment of certain types of bacterial infections such as septicemia, as well as for the treatment of urinary tract infections and the treatment of gonorrhea.
Ciprofloxacin works by targeting the enzymes that are responsible for the bacteria's survival and replication in the gut. This medication prevents the bacteria from multiplying and eliminating them from the gut. This medication is generally taken once a day, with or without food. It is important to note that it does not work for viral infections such as the common cold or flu, nor does it work for viral infections like the common cold or flu that are usually caused by bacteria. Ciprofloxacin will not work for viral infections like the common cold or flu that are usually caused by bacteria.
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